The povidone K30, the English name is Povidone K30, is an organic compound whose molecular formula is (C6H9NO)n, where n represents the average number of 1-vinyl-2-pyrrolidone links. This compound has a wide range of applications in the field of medicine and is one of the three major new medicinal excipients advocated by the international community. The following is a detailed introduction about povidone K30:

basic nature of 1.

Appearance: povidone K30 is white to Milky White powder, odorless or slightly smelly, tasteless, and has strong hygroscopicity.

Solubility: povidone K30 is soluble in water, ethanol, isopropanol or chloroform, but insoluble in acetone or ether.

Stability: acid, salt and heat more stable, has a wide range of uses.

2. preparation method

Povidone K30 is a polymer obtained by a method such as bulk polymerization or solution polymerization using vinyl pyrrolidone (NVP) as a raw material. Specifically, it is formed by the reaction of pyrrolidone and acetylene to form vinyl pyrrolidone monomer under heating and pressure, and then polymerized under the action of an initiator.

Main purpose of 3.

Povidone K30 is widely used in the field of medicine, mainly including the following aspects:

Adhesive: povidone K30 is a very common adhesive, multi-use aqueous solution form used in tablets, granules, powders and other pharmaceutical preparations, can effectively achieve drug bonding, bonding and molding.

Co-solvent: In the injection, povidone K30 can be used as a co-solvent to help the drug better dissolve in the solvent and improve the stability and solubility of the drug.

Stabilizer: povidone K30 can also be used as a stabilizer for enzymes and heat-sensitive drugs, protecting the activity of drugs during storage and use.

Dispersant: In liquid formulations, Povidone K30 can be used as a dispersant to uniformly disperse the drug particles in the solvent and improve the stability and absorption rate of the drug.

Glidant: In the production of capsules, povidone K30 can be used as a glidant to help drug particles fill smoothly into capsules.

Toxicant and Lubricant: In eye medicine, povidone K30 can be used as a detoxicant and lubricant to reduce the irritation and discomfort of the drug to the eyes.

Disinfectant: povidone K30 can also be combined with iodine to PVP-I a disinfectant for medical treatment and disinfection of daily life.

4. storage and preservation

The povidone K30 should be shaded, sealed, and stored in a dry place to avoid moisture absorption and deterioration.

5. considerations

When using povidone K30, it is necessary to pay attention to the control of its amount and the matching of prescriptions to ensure the quality and efficacy of the drug. At the same time, due to its strong moisture absorption, special attention should be paid to moisture resistance during production and storage.

In summary, povidone K30 is an important excipient that has been widely used in the field of medicine, and its unique properties and broad application prospects make it occupy an important position in the pharmaceutical industry.